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Observational data from anti-aging clinics using this protocol report lean mass increases of 24 kg over 6 months in middle-aged adults maintaining isocaloric diets

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As for this specific alternative, the weight loss results are remarkable so far, says Gitanjali Srivastava , MD, co-director of Vanderbilt Weight Loss Clinics

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TRIUMPH-4, the first completed Phase 3 trial, showed 28.7% average body weight loss at 68 weeks on retatrutide 12mg versus 2.1% on placebo, as reported by Eli Lilly in December 2025 (peer-reviewed publication pending)

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