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Limitations include relatively short treatment periods (6 weeks per arm), potential carryover effects despite washout, modest sample size limiting power for subgroup analyses and exclusion of newer agents (e.g., tapentadol) and long-term safety outcomes, which may restrict applicability to broader clinical practice

Optimal ranges: Men under 45 U/L Women under 35 U/L A ratio greater than 2:1 (AST significantly higher than ALT) may indicate alcohol-related liver stress

In such cases, healthcare providers may recommend additional preventive measures

Ko J, Moon SJ

J.VasdevN.et al

By reducing the amount of acid in your stomach, omeprazole can provide significant relief from the reflux caused by slowed digestion