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The most common protocol uses a loading phase of 2 to 2.5 mg twice weekly for 4 to 6 weeks , followed by a maintenance dose of 2 mg once weekly

Though it differs a bit from one person to another, the effects of B12 vitamins usually last around 48 hours to 72 hours after the initial injection

Pyridoxine Hydrochloride (100 mg): Pyridoxine, vitamin B6, plays a crucial role in many chemical reactions in our bodies

The study found that the combination therapy resulted in a significant mean body weight reduction of 20.4% compared to 3.0% with placebo, and was superior to both monotherapies

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Buse, MD, PhD, Distinguished Professor of Medicine, Director of the UNC Diabetes Care Center