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PLoS Med (2004) 1(1):e27.10.1371/journal.pmed.0010027 5 HotamisligilGS

The 2022 Dimet-Wiley paper in Scientific Reports characterised NNMT inhibition combined with reduced-calorie diet in diet-induced-obesity mouse model systems (PMID 35013352)

Coles B, Nowell SA, MacLeod SL, Sweeney C, Lang NP, Kadlubar FF

Best Timing : The optimal time of day for administration to maximize efficacy (e.g., Fasted, Before Bed, Post-Workout)

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Regular exercise training enhances these adaptive responses, leading to elevated baseline antioxidant defenses that exceed sedentary levels