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The biology of oral melanocytes Melanocytes originate from neural crest precursor cells, which during embryogenesis migrate from the neural crest to their ultimate destination in the basal cell layer of the epidermis and of the epithelium of mucous membranes where they differentiate into mature melanin-producing melanocytes with complex network of dendritic processes [14]

Importantly, this region contributes much less to receptor binding than to binding-protein binding, which is what makes the modification useful: it separates the two interactions rather than weakening both