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Bedtime Administration: The Optimal Timing Overwhelming evidence supports bedtime dosing 30-60 minutes before sleep as optimal for several physiologic reasons
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doi: 10.1007/s10620-015-3624-x 64 PasupathiPChinnaswamyPSaravananGKumarUS
These are usually most noticeable early on in treatment or after dose increases and tend to improve as the body adapts to the medication
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