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This extended duration reflects improved resistance to peptidase degradation

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Xie Y, Sakatsume M, Nishi S, Narita I, Arakawa M, Gejyo F (2001) Expression, roles, receptors, and regulation of osteopontin in the kidney

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This dual-pathway nitric oxide production through both citrulline and beet root creates a broader, more sustained vasodilation effect than either ingredient produces independently