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Consult with a healthcare provider if you are taking these medications

52 The effect of semaglutide on HRQoL in HFpEF, particularly social and physical function as measured by the KCCQ, is mediated at least in part by the effect on weight reduction

These findings support the concept that glucagon receptor activation may be therapeutically useful when balanced by GLP-1 receptor signaling, although retatrutide currently provides the most prominent evidence for triple receptor agonism

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The FDA has approved specific formulations for different indications: semaglutide 2.4 mg (Wegovy), liraglutide 3 mg (Saxenda), and tirzepatide (Zepbound) are approved for chronic weight management, while all are approved for diabetes at different doses