Concurrent alcohol intake lowers these thresholds significantly
The key comparison was between the KC group (KD with biotin) and the KBD group (KD without biotin), which allowed the researchers to assess whether KD alone increases biotin requirements or accelerates the development of biotin deficiency
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Importantly, evidence also shows that several polyphenols including EGCG, quercetin, curcumin and resveratrol modulate chromatin-remodeling enzymes such as DNMTs, HATs and HDACs, reinforcing their broad epigenetic impact beyond antioxidant and anti-inflammatory mechanisms ( In addition, polyphenols affect histone modifications, which regulate chromatin accessibility and transcriptional activity