The current work focuses on optimizing the half-life and CNS penetration to translate these findings into viable clinical candidates [62]
Overall, non-presentation of some cell types in such models, the absence of blood flow, and a lack of metabolic and neurochemical coupling between the neuronal cells and the barrier components limit the implication of these models (Bagchi et al., 2019)
Int J Neuropsychopharmacol 2008
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A 1 mL reconstitution gives both at 5 mg/mL