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Presented for research literature review only Zemba M et al

MR: Conceptualization, Writingreview and editing

Some patients need slower dose escalation, while others tolerate standard increases

172 Genes involved in pathways related to oxidative stress and antioxidant defense might therefore be potential genetic modifiers in AATD-related liver diseases, and warrant further investigation

However, further dose-response analysis and adjustment for intake of other vitamin and mineral supplements indicated that all-cause mortality risk was significantly increased by 7% only at a dose of 2,000 IU/day, which is notably higher than the UL for adults (1,100 IU/day of synthetic tocopherol or 1,500 IU/day of natural tocopherol)

Serving Size: 12 sprays (~2 ml) Amount Per Serving: Proprietary Blend