This condition, known as melena, can point to serious health problems
Melanotan-2 Side Effects MT-2's multi-receptor activation causes significantly more side effects: Nausea (very common, especially during loading the #1 complaint) Facial flushing (common, more intense than MT-1) Spontaneous erections (common in men, MC4R-mediated) Increased libido (both sexes, MC4R-mediated) Appetite suppression (common, MC4R-mediated) Fatigue/drowsiness (common post-injection) Mole/freckle darkening (more pronounced than MT-1) Injection site pain (variable) The nausea during MT-2 loading is significant enough that many users inject before bedtime to sleep through the worst of it
Comparative data from rhGH trials provide indirect context
Protein turnover releases - N -trimethyllysine, which is hydroxylated by - N -trimethyllysine hydroxylase in a reaction requiring Fe 2+ and ascorbate, producing -hydroxy-- N -trimethyllysine
Neurosci Biobehav Rev 79:6686
Methods of use: Apply an appropriate amount to clean, dry skin