glp 1 discovery of a new GLP-1 receptor agonist using DNA encoded-libraries and similarity search History of GLP-1: From Discovery

The average follow-up was 22 months, and the composite kidney outcome showed a smaller decline in eGFR (glomerular filtration rate) at all time points after 12 months

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A study published in 2021 showed positive results from once-weekly semaglutide in obese or overweight adults

Conversely, resmetirom may be preferable in patients with normal body weight or in those who have not responded adequately to GLP-1-based strategies

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