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10.1038/s41418-019-0380-z 289 WangP.WangZ.LiuJ

A decrease in oxygen supply, resulting in hypoxia is also strongly connected with breakdown of the BBB, resulting in increased oxidative stress and permeability

The in vitro GST pull-down assay using GST, GST-FUS and GST-TDP-43 with equal amount of recombinant SMN proteins performed as described above

Researchers isolated this specific fragment because it demonstrated the most potent biological activity among all the fragments tested