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Connexin hemichannel blockade is neuroprotective after, but not during, global cerebral ischemia in near-term fetal sheep
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It should be avoided with active cancer, and it is not used during pregnancy or breastfeeding
Rather than being a pharmaceutical development, this tripeptide occurs naturally in human blood plasma, with concentrations around 200 ng/mL at age 20 that decline to approximately 80 ng/mL by age 60
Hence, it was hypothesized that p53 acted as a survival factor under limiting oxygen concentrations [91]
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