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Mounjaro (tirzepatide) is a prescription medicine licensed in the UK for the treatment of type 2 diabetes mellitus and, more recently, for chronic weight management in adults with obesity or overweight with weight-related comorbidities, as per the MHRA authorisation

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Instead of pushing every patient to the maximum dose, clinicians may maintain individuals at lower doses that still produce meaningful metabolic effects

| Substance | Receptor profile | Trial | Weight change | Placebo | | --- | --- | --- | --- | --- | | Retatrutide | GIP/GLP-1/glucagon | Phase 2 (48 wk) | -8.7 to -24.2 % | -2.1 % | | Tirzepatide | GIP/GLP-1 | SURMOUNT-1 (72 wk) | -16.0 to -22.5 % | -3.1 % | | Semaglutide | GLP-1 | STEP 1 (68 wk) | -14.9 % | -2.4 % | | Cagrilintide + semaglutide | Amylin + GLP-1 | Phase 1b (20 wk) | -15.7 to -17.1 % | -9.8 %* | | CagriSema | Amylin + GLP-1 | REDEFINE 1 (68 wk) | -20.4 % | -3.0 % | *Comparator arm semaglutide alone

Together, these effects support gradual, consistent weight loss over time

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