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As a statement made by one of the leaders in vitamin B12 field more than 10 years ago, Carmels idea of cobalamin deficiency should not be diagnosed unless megaloblastic changes are found is still followed by many physicians and health authorities when accepting B12 deficiency diagnosis.1 But as time goes by, evidence and clinical cases showed that B12 deficiency symptoms can be seen even when B12 level in blood is within the reference range, as 200 900 pg/mL in the United States,2 and 135-650 pmol/L in Australia.3 In clinical practice, signs and symptoms of B12 deficiency start when plasma B12 levels are normal, and long historical studies showed that neurological symptoms of deficiency occur in patients without sign of anaemia
Youre over 60 years old and can benefit from B12 supplementation
A vitamin B12 deficiency can develop slowly and symptoms may include: Persistent tiredness or low energy Shortness of breath Pale skin Pins and needles Memory or concentration difficulties If left untreated, deficiency can lead to more serious neurological complications
About The Author Dr
Safia Pirani, MD, consider the patients symptoms, medical history, blood test results, severity and cause of deficiency, absorption concerns, current medications, and response to previous supplementation
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