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For example, a study should not claim a calcium mechanism unless calcium was measured, and it should not claim a cAMP mechanism unless cAMP or a closely linked marker was measured

If you're talking about blood sugar and fullness signals and all that, it makes sense that you're doing it with meals, although I could see why people might think doing it between meals could have its own positive effect of potentially reducing your hunger signals, for example

This is especially risky for people who are already taking other diabetes medications like metformin or insulin

Polycystic ovary syndrome (PCOS)

However, as with any research compound, potential for temporary skin reactions exists, and careful observation is always recommended