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These findings have sparked intense scientific interest in understanding the mechanics underpinning these observations, with most studies aiming to establish where these drugs act primarily on the brain's reward centers, like addiction medications like naltrexone, or if they work through a more physical, peripheral mechanism in the body

Swim latency, swim distance, time spent in the target quadrant, and number of quadrant crossings were recorded using a computerized video tracking system [2]

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2 Methodology We conducted a structured literature search using PubMed, Web of Science, and Scopus databases for studies published between January 2010 and March 2025

Cell Death Dis 9:331

The good news: this potentiation is reversible once the stimulus (the drug) is removed or the nervous system adapts