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KangSHuangJLeeBKJungYSImEKohJMet al

Without carefully designed mechanistic experiments, it is difficult to determine whether the peptide acts directly within central compartments or indirectly through peripheral vascular, immune, or gut-brain signaling pathways

Unlike stimulant-based weight loss medications, GLP-1 and dual GIP/GLP-1 agonists do not function primarily as metabolic stimulants or thermogenic agents

Flow diagrams of these cohort designs were provided in in Supplementary Figure S1-S5

These associations persisted after adjustment for conventional risk factors including BMI, blood pressure, and lipids