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By activating glucagon-like peptide-1 (GLP-1) receptors, retatrutide stimulates insulin secretion from pancreatic beta cells and inhibits glucagon release

Reconstitution and handling Retatrutide is supplied as a lyophilised vial and should be handled using standard peptide reconstitution procedures appropriate to the research setting

However, the effects on IL-6 and IGF-1 were favorable

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