ROS, also as a second messenger, can activate tyrosine kinases and MAPK which promote cell development (81), and the protein kinase-B (Akt)/mTOR signaling pathway which promotes cell growth of gastric cancer (82)
87 In addition to systemic effects on glucose metabolism and insulin sensitivity, GH may contribute to diabetes-associated complications, such as diabetic retinopathy and diabetic renal disease, through localized expression and autocrine/paracrine effects in tissues, 88,89,90,91,92,93 although published research in these areas is limited
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