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Metformin was selected as first-line treatment because of its record of safety and efficacy, as well as its low cost (Gold Standard 2015c)

Polyunsaturated fatty acids of germ cell membranes, glutathione (GSH) and glutathione-dependent enzyme-PHGPx: from basic to clinic

As for the mechanisms of hypotensive effect beyond BW, augmentation of natriuresis by inhibiting sodium hydrogen exchanger at proximal tubule, ameliorating angiotensin II activity, and enhancing vasodilation can be postulated

However, they do not have the side effects associated with meds, they can offer sustainable weight loss, and they support healthy lifestyle habits

Liver disease: Regular liver tests are important