This review reflects the potential importance of the vitamin B12 assay as an early diagnostic marker of these diseases
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Furthermore, there is an important connection between the permeabilization of mitochondria outer membrane and autophagy, as p62 serves as a tag regulating PUMA degradation, leading to a reduced apoptosis (Thorburn et al., 2014)
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This is one of the reasons regulators and dermatologists raise concern, since changes in moles can complicate skin-cancer monitoring
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