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Advertisement This therapeutic expansion has contributed to increased referrals from primary care, internal medicine, endocrinology, and cardiology, as well as from obesity and lifestyle medicine programs, like the one established at Weston Hospital

The American Diabetes Association's Standards of Care recognize GLP-1 receptor agonists with proven cardiovascular benefit as preferred agents for patients with established atherosclerotic cardiovascular disease or indicators of high cardiovascular risk

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Additional safety information MHRA (April 2016): Updated advice on the risk of diabetic ketoacidosis MHRA (March 2017): Updated advice on increased risk of lower-limb amputations (mainly toes) MHRA (February 2019): Reports of Fourniers gangrene (necrotising fasciitis of the genitalia or perineum) MHRA (March 2020): Monitor ketones in blood during treatment interruptions for surgical procedures or acute serious medical illness Key summary table See also Need to know guide: SGLT2 inhibitors: Indications, doses and licences in adults How to: How to use SGLT2 inhibitors safely and effectively

Unnikrishnan A G, Chief Endocrinologist and CEO of the Chellaram Diabetes Institute, highlighted that GLP-1 receptor agonists such as semaglutide represent an important scientific advancement for overall metabolic health, not just weight reduction

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