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Clinical trials for XIAFLEX evaluated the Bother domain score, which is a composite of the following patient-reported items: concern about erection pain, erection appearance, and impact of Peyronies disease on intercourse and on frequency of intercourse

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multi-peptide activity Gene expression research related to structural protein regulation Multi-pathway exploratory studies in regenerative biology, where combined peptide exposure is used to compare single- vs multi-peptide effects on matrix markers, cell motility, and gene-expression profiles in vitro