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2014, 13:142 GLP-1R Signaling Binding of GLP-1 to GLP-1R triggers a downstream signaling cascade that induces a potent stimulation of glucose induced insulin secretion (GIIS) in pancreatic beta-cells, as well as inhibition of alpha cell glucagon release (6)

Recently, the concept of a "metabolic diapause" has been proposed for the changes induced by FoxO1 to protect -cells against oxidative stress underpinning the concept of -cell rest as a treatment goal in T2D [11]

To view a copy of this licence, visit About this article Cite this article Mosterd, C.M., Bjornstad, P

It is not approved by the FDA for any indication and is available primarily through compounded sources without standardized regulatory oversight