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Avsar YK, Karagul-Yuceer Y, Drake MA, Singh TK, Yoon Y, Cadwallader KR

Given their dual benefits in obesity and inflammation regulation, GLP-1RAs medications hold potential as disease-modifying therapies for OA

32 GST in regulation of MAPK pathway Besides metabolite detoxification, GST also exhibits ligand-binding properties that allow the enzyme to interact covalently and noncovalently with compounds, resulting in inhibition of conjugation activity

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Furthermore, specific alterations in microRNA (miRNA) expression profiles (e.g., miR-146a, miR-27b-3p) have been identified as sensitive indicators of epigenetic disruption, modulating downstream pathways involved in cell cycle control, metabolism, and stress responses [165,166,167]

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