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The prospective, single-arm phase II Keystone-001 trial evaluated three cycles of neoadjuvant pembrolizumab plus paclitaxel and cisplatin, specifically for resectable stage III ESCC

This action may counter the aberrant glycolytic shift observed in immune cells, potentially alleviating T cell exhaustion and improving insulin sensitivity, leading to clinical trials assessing its impact on inflammation and comorbidities (156158)

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Additional blood tests can look for genetic fungi particles present in the bloodstream

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Do not take it with dairy or high-protein foods, which can obstruct absorption