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Melatonin: buffering the immune system [PMID: 23609496] Laboratory literature summary: Melatonin: buffering the immune system

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Wang Y, Kelly MA, Cowan TM, Longo N: A missense mutation in the OCTN2 gene associated with residual carnitine transport activity

It activates several overlapping pathways, notably VEGFR2 and nitric oxide synthesis via the Akt-eNOS axis, promoting angiogenesis, fibroblast activity, and neuromuscular stabilization

They can enhance blood flow and stimulate collagen production, which aids in healing injuries to muscles, tendons, and ligaments

Collectively, these factors provide a biologically and methodologically plausible basis for divergent findings across outcomes