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KEY TAKEAWAYS Metabolic dysfunction cannot be judged by scale weight alone

There's a lot of diseases that don't have good treatments

Additionally, a pilot randomized trial reported that short-term combination treatment with beinaglutide and metformin was more effective than metformin monotherapy in lowering body weight, improving insulin sensitivity, and reducing androgen excess in women living with PCOS and obesity [33]

Glickman notes

357 In addition, cGAMP synthesized by cGAS can be transmitted to adjacent cells via gap junctions, engaging plasma membrane-bound STING and triggering a similar response

Read the full study: Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolism (Am J Physiol Endocrinol Metab 2000)