Renal expression of rGLP-1 has not been fully characterized due to insufficient specificity and sensitivity of the antibodies used, although it have been non-uniformly detected in endothelial cells, macrophages, juxtaglomerular cells and proximal tubule in several animal models and human tissue
Chen, X., Li, J., Kang, R., Klionsky, D
What the GLP-1 Conversation Is Getting Wrong Here is what gets left out: eating disorders are common in the very population most likely to be prescribed GLP-1 medications
Triple-Hormone-Receptor Agonist Retatrutide for Obesity A Phase 2 Trial [published online ahead of print, 2023 Jun 26]
Bupropions dopaminergic effects can further reduce food-related reward signaling in some patients
Because of its unclear regulatory status, athletes should weigh the benefits against potential risks and test failures especially when preparing for competitions or under a physician-monitored plan