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10.1016/j.cell.2017.11.048 29 JiaM.QinD.ZhaoC.ChaiL.YuZ.WangW.et al (2020)

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Although oxidative damage in biological systems has in the past been completely attributed to ROS, it is becoming increasingly clear that also reactive nitrogen species (RNS) and reactive sulfur species (RSS) are integral components of signal transduction processes in cells, and play important roles in OS generation [2, 25, 35]

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Five children with neither supplementation nor a known chronic illness were later diagnosed with a malignancy, including chronic myeloid leukemia

However, 44% of patients only respond to PN, probably due to residual enzyme activity that converts PN to PLP [37]