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More specifically speaking, the mechanism potentially involved downregulation of macrophage CD11b, which played a vital role in monocyte adhesion, as well as decreased expression of macrophage modulators including CXCL-10, CXCL-1, C-C motif chemokine ligand-1 (CCL-2) and tissue inhibitor of metal protease-1 (TIMP-1) (Robinson et al., 2015)

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The diet consists of 1600 kcal/day with 2030% fats, 5055% carbohydrates, and 1520% protein, while sodium intake is less than 2.4 g/day [163]

GLP-1 travels to the brain and influences the appetite centres, promoting satiety and reducing hunger

You should contact your GP or mental health team urgently if you experience any of the following whilst taking Mounjaro: Significant changes in mood (either elevated or depressed) Increased anxiety or agitation Changes in sleep patterns (insomnia or excessive sleeping) Thoughts of self-harm or suicide (if at immediate risk, call 999 or go to A&E) Severe or persistent gastrointestinal symptoms affecting your ability to eat or take medications Signs of dehydration Symptoms of hypoglycaemia if also taking insulin or sulfonylureas (shakiness, sweating, confusion) Additionally, seek medical advice if you notice any unusual physical symptoms such as: Severe abdominal pain Persistent vomiting Signs of pancreatitis (severe upper abdominal pain radiating to the back) Symptoms of gallbladder disease (pain in the right upper abdomen, fever, jaundice) Symptoms of thyroid problems (lump in the neck, hoarseness, difficulty swallowing) Changes in vision, particularly if you have diabetic retinopathy While rare, these require prompt medical assessment

The effect wasnt large enough to call semaglutide an antidepressant, and both groups remained in the minimal depression range