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& Stagg, J
Numerous BACs derived from natural sources- such as curcumin, resveratrol, omega-3 polyunsaturated fatty acids, various vitamins, and polyphenolic compounds- have been extensively demonstrated to exert potent antioxidant, anti-inflammatory, and other biofunctional activities in controlled experimental settings (38)
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All three peptides distribute systemically after subcutaneous injection, but local tissue concentrations are highest within a 5 to 10 cm radius of the injection site
As such, the model was used to simulate how long it would take pharmacologically and toxicologically relevant concentrations of doxorubicin to yield a 70% reduction in GSH concentration, indicative of impaired cellular antioxidant defence, protein binding and cell death 19
