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After the drug loading, in order to avoid unnecessary leakage of drugs under physiological circulation conditions and endow the nanotherapeutic platform with ideal tumor targeting ability, the drug-loading NPs were immersed in a dopamine Tris solution and a PDA shell was wrapped on the surface of the nanoparticles by the self-polymerization of dopamine under alkaline conditions, followed by folic acid modification (Figure 1C and Figure S4 )

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Loumbakis P, Anezinis P, Evangeliou A, and et al