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2019 ACC/AHA guideline on the primary prevention of cardiovascular disease: executive summary: A report of the american college of cardiology/american heart association task force on clinical practice guidelines

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As little as one year off the drug was more than enough for study participants to lose benefits cultivated over years of continuous treatment

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The addition of exogenous ROS results in resensitization of cells with high VRK2 expression to GSH inhibition, which is consistent with the fact that PC cells with low expression of VRK2 are susceptible to GSH inhibition attributes to its high basal ROS level, suggesting that cells in a state of oxidative stress have enhanced dependence on the GSH system