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Orforglipron: Lillys oral GLP-1 Orforglipron showed positive results in four Phase 3 trials, Lilly said last Thursday

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If you mean: most established and widely used the answer is semaglutide

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Popularized by celebrities (it seems everyone is admitting to losing weight because of these drugs), semaglutide medications (GLP-1 agonists) were designed to help lower blood sugar in diabetics but were found to have the benefit of weight loss as well