doi: 10.1016/j.cell.2020.12.040 172 RyuK
Since the FDA approved the first GLP-1 medicationByetta (exenatide)in 2005, clinicians have observed that GLP-1s not only support blood sugar control but also contribute to weight loss and other metabolic health improvements
This enables users to feel full longer and can lead to weight loss
They are released throughout the day, increasing at mealtimes, and have several functions: Stimulate the production and secretion of insulin in response to eating (glucose-dependent insulin secretion) GLP-1 enhances the sensitivity of alpha cells to glucose, resulting in more glucose-appropriate glucagon secretion Slow digestion and decrease appetite Thus, DPP-4 inhibitors indirectly enhance insulin release, suppress glucagon secretion, and improve glycaemic control
Enhanced Cellular Regeneration By stimulating natural GH, the stack promotes the synthesis of Insulin-like Growth Factor 1 (IGF-1)
How successful is tirzepatide for weight loss