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Thank you to Ilaria Calvello (Tony Blair Institute for Global Change) and Carsten Edwards for reviewing and commenting on earlier versions of the technical paper

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A small pilot study conducted in 2006 randomizing individuals with HFrEF between orlistat and placebo, gave early evidence for improvements in functional capacity with weight loss [50]

Individual results will vary based on factors including age, baseline health condition, starting weight, lifestyle factors, consistency of use, genetic factors, current medications, dietary adherence, physical activity levels, and other individual variables

We will also explore how to safely transition between treatments if your current plan is no longer meeting your needs