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Tirzepatide alone produces significant weight lossclinical trials show average reductions of 20-22% body weight over 68 weeksmaking additional lipotropic support potentially unnecessary for many patients
Visible Weight Loss : By 8-12 weeks, most patients begin to see more noticeable weight loss
A significant benefit in reducing death from cardiovascular causes was only shown in the LEADER trial with liraglutide (HR 0.78
And in the other
Dose reductions of insulin or sulfonylureas may be needed to prevent hypoglycaemia
Metformin (The Old Reliable) Metformin is a safe, cheap, and effective drug for insulin sensitivity
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