how to avoid muscle loss on glp-1 GLP1 weight-loss medications: they work and tips for success | JAMA posted the topic How to Prevent GLP-1 Muscle

Wang J, Huangfu M, Li X, Han M, Liu G, Yu D, et al

Z.NewtonY.VaskeC.et al (2020)

Bariatric surgery often leads to a 60% to 70% reduction in excess body weight, while GLP-1 medications like semaglutide typically result in a 15-20% total body weight loss

Similarly, the front of the upper thighs and back of the upper arm are also optimal sites for semaglutide injection

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This is the mechanistic basis for claims about mood and neurological effects, but the chain of inference from rodent dopamine modulation to human mood benefit is long and unvalidated