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Weight loss and lifestyle changes have proven to be effective in restoring menstrual regularity and reproductive function, improving hyperandrogenism, glucose and lipid metabolism, and insulin sensitivity, thus reducing cardiovascular risk in women with PCOS [18,19,20]

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[10] Pharmacodynamic modeling indicates that exposure-response curves plateau near 20 mg, but the long half-life sustains clinically relevant plasma levels for up to 36 hours, allowing on-demand dosing flexibility and once-daily regimens for chronic indications

Protocols, as provided in the manufacturers instructions, were followed, including the use of appropriate controls and standards

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