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That list sits alongside its broader point that selection should be a single-agent decision made with a clinician rather than a self-assembled combination

The black box warning highlights a potential risk for thyroid C-cell tumors

NICE NG28: A Major First-Line Shift The most significant structural change in NICE NG28s February 2026 update: metformin combined with an SGLT-2 inhibitor is now the standard first-line therapy for virtually all adults with type 2 diabetes, regardless of comorbidities

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We know GLP-1s affect parts of the brain involved in reward