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Together, these modifications produce a compound reported to be approximately 26-fold more potent than native -MSH in adenylyl cyclase assay systems, positioning MT1 as a common reference compound in MC1R pharmacology and melanogenesis pathway research

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This structure has been proposed as a fragment derived from collagen, particularly from the alpha 2(I) chain of type I collagen

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Dev Brain Res 55(2):283

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