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Int J Mol Sci, 2022, 23(11)

Ubiquitination also regulates ferroptosis by modulating ferritin degradation

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The authors elucidated a mechanism wherein MCT1-mediated lactate uptake promotes ATP production, leading to AMPK deactivation and subsequent upregulation of SREBP1 and SCD1, enhancing the production of MUFAs that confer protection against ferroptosis (57)

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