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GLP1R agonists increase heart rate and might not be beneficial in individuals with severe left ventricular dysfunction, reduced ejection fraction and/or a history of repeated hospitalization for heart failure

2024;73(Supplement_1):791P

ACE inhibitor or angiotensin II receptor antagonist attenuates diabetic neuropathy in streptozotocin-induced diabetic rats

Increased Risk of Heart Disease (In Some Cases) Some studies have suggested that high levels of L-carnitine might promote the formation of trimethylamine-N-oxide (TMAO) in the body, which has been linked to an increased risk of atherosclerosis (hardening of the arteries) and heart disease

All animal experiments were conducted using male mice and approved by the Institutional Animal Care and Use Committee of Shonan Research Center (AU-00040058)