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By enhancing fatty acid oxidation, it may reduce the body need to break down protein for energy
& Tian, R
The consequences of PPAR activation by bempedoic acid is enhanced hepatocyte fatty acid -oxidation and a consequent reduction in lipid content in the hepatocytes
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The medicinal-chemistry programme that produced cagrilintide, described by Kruse and colleagues in the Journal of Medicinal Chemistry in 2021, addressed this by re-engineering the amylin backbone with structural elements borrowed from calcitonin (a related, non-aggregating peptide) and attaching a fatty-acid side chain that enables reversible binding to serum albumin [1]
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