Although its not fully understood, several factors appear to be at play: 1
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Because B12 is water-soluble, the NIH Office of Dietary Supplements notes that no tolerable upper intake level has been established excess B12 is excreted by the body rather than accumulating to toxic levels
The side effects of high vitamin B12 can vary, but might be present
This case underscores that regulatory bodies consider it professional misconduct to experiment on patients with dubious therapies