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BV and melittin influence several intracellular pathways, and their blockage triggers apoptosis., melittin inhibits the PI3K/Akt/mTOR pathway in breast cancer cells (Pandey et al., 2023b), or liver cancer cells (Lv et al., 2023)
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However, it is equally important to explore other potential causes, such as poorly controlled blood glucose levels, thyroid dysfunction, vitamin deficiencies, or sleep disorders, all of which can affect mood
Yet, whether Rho/ROCK directly mediates TGR5 effects in vivo remains to be confirmed by additional experiments, such as in vivo gene knockout models and Western blot analysis of hypothalamic tissue [68]
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Rat studies have also shown positive results
